Research News

Yin Yang 1 Orchestrates a Metabolic Program Required for Both Neural Crest Development and Melanoma Formation

A joint research project lead by the CRC Members Reinhard Dummer (Department of Dermatology, USZ) und Lukas Sommer (Institute of Anatomy, UZH) showed that the transcription factor YY1 is required for both Neural Crest (NC) development and melanoma formation by regulating metabolism and translation. These findings support the notion that cancer cells highjack developmental programs for disease initiation and progression. READ MORE


ARTICLE
Sandra Varum, Arianna Baggiolini, Luis Zurkirchen,Zeynep Kalender Atak, Claudio Cantu, Elisa Marzorati, Raphael Bossart, Jasper Wouters, Jessica Häusel, Eyleul Tuncer, Daniel Zingg, Dominiek Veen, Nessy John, Marcel Balz, Mitchell P. Levesque, Konrad Basler, Stein Aerts, Nicola Zamboni, Reinhard Dummer, and Lukas Sommer.  Yin Yang 1 Orchestrates a Metabolic Program Required for Both Neural Crest Development and Melanoma Formation. Cell Stem Cell 2019; 24, 637–653

CORRESPONDENCE
lukas.sommer@anatomy.uzh.ch


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